Reproducibility of the blood flow index as noninvasive, bedside estimation of cerebral blood flow
- 21 January 2003
- journal article
- research article
- Published by Springer Science and Business Media LLC in Intensive Care Medicine
- Vol. 29 (2), 196-200
- https://doi.org/10.1007/s00134-002-1592-z
Abstract
To investigate the feasibility and reproducibility of the blood flow index (BFI) method for measuring cerebral blood flow. Prospective functional study in pediatric intensive care. 14 consecutive patients with median age of 2 months (range 1 days-11 years) requiring artificial ventilation, invasive arterial blood pressure monitoring, and central venous access. The first passage of an intravenous indocyanine green (ICG) bolus through the cerebral vasculature was monitored by noninvasive near-infrared spectroscopy. BFI was calculated by dividing maximal ICG absorption change by rise time. Reproducibility was evaluated by six ICG injections at 5-min intervals. Of all ICG injections 6% were canceled, and 4% were eliminated due to injection failures. Median BFI of 17 reproducibility determinations was 71 (range 12-213) and median coefficient of variation (CV) of BFI was 10% (4.9-18.5). The quantity of ICG bolus did not affect the CV (0.1 vs. 0.3 mg ICG/kg). Eight reproducibility tests in patients after cardiac surgery had smaller CV than the others, and the eight in newborns had higher CV than in older children. Patient parameters such as arterial blood pressure, endtidal CO(2), and percutaneous oxygen saturation were stable and showed CV below 2% during reproducibility determination. The BFI method allows rapid and repeated measurements of CBF with good feasibility and reproducibility. As a relative but not absolute measure of CBF, BFI seems to be suited for clinical evaluation of intraindividual CBF changes during determination of cerebrovascular reactivities or during therapeutic interventions.Keywords
This publication has 26 references indexed in Scilit:
- Bedside Monitoring of Cerebral Blood Flow by Transcranial Thermo-Dye-Dilution Technique in Patients Suffering from Severe Traumatic Brain Injury or Subarachnoid HemorrhageJournal of Neurotrauma, 2001
- Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobeJournal of Neurosurgery, 2000
- Measurement of Cerebral Blood Flow Volume by Extracranial SonographyJournal of Cerebral Blood Flow & Metabolism, 2000
- Quantification of Cyclical Fluctuations in Cerebral Blood Volume in Healthy InfantsNeuropediatrics, 1998
- Measurement of Cerebral Blood Flow in Dogs with Near Infrared Spectroscopy in the Reflectance Mode Is InvalidJournal of Cerebral Blood Flow & Metabolism, 1997
- Can Cerebrovascular Reactivity Be Measured With Near-Infrared Spectroscopy?Stroke, 1995
- Qualitative comparison of carbon dioxide-induced change in cerebral near-infrared spectroscopy versus jugular venous oxygen saturation in adults with acute brain diseaseCritical Care Medicine, 1995
- Vasomotion in the rat cerebral microcirculation recorded by laser‐Doppler flowmetryActa Physiologica Scandinavica, 1992
- Transport of sodium fluorescein between the mucosal and muscular layers in man, possibly indicating functional serially‐coupled exchange vesselsClinical Physiology and Functional Imaging, 1985
- Adverse reactions after administration of indocyanine greenPublished by American Medical Association (AMA) ,1978