InVitro Activity of Tigecycline against Staphylococcusepidermidis Growing in an Adherent-Cell BiofilmModel
Open Access
- 1 December 2003
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (12), 3967-3969
- https://doi.org/10.1128/aac.47.12.3967-3969.2003
Abstract
The activity of tigecycline against Staphylococcus epidermidis growing in an in vitro adherent-cell biofilm model was determined. Tigecycline minimum bactericidal concentrations (MBCs) ranged from 1 to 8 μg/ml for S. epidermidis growing in a biofilm of adherent cells, compared to MBCs of 0.12 to >32 μg/ml for freely growing cells. The killing activity of tigecycline against the adherent bacteria was at least fourfold better than that of vancomycin and daptomycin.Keywords
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