Alprazolam in Panic Disorder and Agoraphobia: Results From a Multicenter Trial
- 1 May 1988
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 45 (5), 413-422
- https://doi.org/10.1001/archpsyc.1988.01800290027004
Abstract
• Following promising preliminary evidence, the benzodiazepine-derivative alprazolam was studied in a large, placebocontrolled, eight-week, flexible-dose trial in patients with agoraphobia with panic attacks and panic disorder. Of 526 patients, 481 completed three weeks of treatment; however, significantly more placebo (102/234) than alprazolam (21/247) recipients subsequently dropped out of the trial, primarily citing ineffectiveness (of placebo) as the reason. Alprazolam was found to be effective and well tolerated. There were significant alprazolam-placebo differences in improvement for (1) spontaneous and situational panic attacks, (2) phobic fears, (3) avoidance behavior, (4) anxiety, and (5) secondary disability, all significant by the end of week 1. At the primary comparison point (week 4), 82% of the patients receiving alprazolam were rated moderately improved or better vs 43% of the placebo group. At that point, 50% of the alprazolam recipients vs 28% of placebo recipients were free of panic attacks.Keywords
This publication has 31 references indexed in Scilit:
- Antidepressants in panic disorder and agoraphobiaJournal of Affective Disorders, 1987
- Trazodone in the treatment of panic disorder and agoraphobia with panic attacksAmerican Journal of Psychiatry, 1987
- Combined pharmacological and behavioral treatment for agoraphobiaBehaviour Research and Therapy, 1985
- Imipramine and Brief Therapist-Aided Exposure in Agoraphobics Having Self-exposure HomeworkArchives of General Psychiatry, 1983
- Treatment of Agoraphobia With Group Exposure In Vivo and ImipramineArchives of General Psychiatry, 1980
- Treatment of Endogenous Anxiety With Phobic, Hysterical, and Hypochondriacal SymptomsArchives of General Psychiatry, 1980
- Treatment of Phobic States with AntidepressantsThe British Journal of Psychiatry, 1970
- Delineation of two drug-responsive anxiety syndromesPsychopharmacology, 1964
- PSYCHIATRIC REACTION PATTERNS TO IMIPRAMINEAmerican Journal of Psychiatry, 1962
- Treatment of Anxiety States by Antidepressant DrugsBMJ, 1962