Hybrid Integrated Label-Free Chemical and Biological Sensors
Open Access
- 26 March 2014
- Vol. 14 (4), 5890-5928
- https://doi.org/10.3390/s140405890
Abstract
Label-free sensors based on electrical, mechanical and optical transduction methods have potential applications in numerous areas of society, ranging from healthcare to environmental monitoring. Initial research in the field focused on the development and optimization of various sensor platforms fabricated from a single material system, such as fiber-based optical sensors and silicon nanowire-based electrical sensors. However, more recent research efforts have explored designing sensors fabricated from multiple materials. For example, synthetic materials and/or biomaterials can also be added to the sensor to improve its response toward analytes of interest. By leveraging the properties of the different material systems, these hybrid sensing devices can have significantly improved performance over their single-material counterparts (better sensitivity, specificity, signal to noise, and/or detection limits). This review will briefly discuss some of the methods for creating these multi-material sensor platforms and the advances enabled by this design approach.Keywords
This publication has 197 references indexed in Scilit:
- Selective patterning of Si-based biosensor surfaces using isotropic silicon etchantsJournal of Colloid and Interface Science, 2012
- Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics SimulationsJournal of Chemical Information and Modeling, 2010
- An Optofluidic Nanoplasmonic Biosensor for Direct Detection of Live Viruses from Biological MediaNano Letters, 2010
- Integration of a Chemical‐Responsive Hydrogel into a Porous Silicon Photonic Sensor for Visual Colorimetric ReadoutAdvanced Functional Materials, 2010
- Label-Free Biomarker Sensing in Undiluted Serum with Suspended Microchannel ResonatorsAnalytical Chemistry, 2010
- Silicon Photonic Microring Resonators for Quantitative Cytokine Detection and T-Cell Secretion AnalysisAnalytical Chemistry, 2010
- Label-Free Quantitation of a Cancer Biomarker in Complex Media Using Silicon Photonic Microring ResonatorsAnalytical Chemistry, 2009
- Microfabricated implants for applications in therapeutic delivery, tissue engineering, and biosensingLab on a Chip, 2008
- Quantitative and Label-Free Technique for Measuring Protease Activity and Inhibition using a Microfluidic Cantilever ArrayNano Letters, 2008
- Sequence-specific detection of individual DNA polymerase complexes in real time using a nanoporeNature Nanotechnology, 2007