Misexpression of Wingless-Related MMTV Integration Site 5A in Mouse Mammary Gland Inhibits the Milk Ejection Response and Regulates Connexin43 Phosphorylation1
Open Access
- 1 November 2011
- journal article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 85 (5), 907-915
- https://doi.org/10.1095/biolreprod.111.091645
Abstract
Lactation defines the ability of mammals to feed their young. The mammary gland fully develops during pregnancy and is at its most productive during lactation [ 1, 2]. Milk production and secretion are vital for nutrition and survival of neonatal mammals. Despite the obvious importance of lactation, the local mechanisms regulating the onset of lactation are not well understood. During pregnancy hormonal stimulation, mostly through estrogen, progesterone, and prolactin, drives formation of lobulo-alveolar structures, the milk producing unit of the mammary gland [ 1, 3]. In murine mammary glands, lobulo-alveolar structures develop during pregnancy.Keywords
This publication has 38 references indexed in Scilit:
- Pregnancy Enhances Sustained Ca2+ Bursts and Endothelial Nitric Oxide Synthase Activation in Ovine Uterine Artery Endothelial Cells Through Increased Connexin 43 Function1Biology of Reproduction, 2010
- A Versatile Viral System for Expression and Depletion of Proteins in Mammalian CellsPLOS ONE, 2009
- A Dominant Loss-of-Function GJA1 (Cx43) Mutant Impairs Parturition in the Mouse1Biology of Reproduction, 2009
- Loss of TGF-β or Wnt5a results in an increase in Wnt/β-catenin activity and redirects mammary tumour phenotypeBreast Cancer Research, 2009
- Connexin43 phosphorylation: structural changes and biological effectsBiochemical Journal, 2009
- Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of β-catenin in miceGenes & Development, 2008
- Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasiaDevelopmental Biology, 2008
- Connexins Act as Tumor Suppressors in Three-dimensional Mammary Cell Organoids by Regulating Differentiation and AngiogenesisCancer Research, 2006
- Regulation of Wnt signaling by protein-protein interaction and post-translational modificationsExperimental & Molecular Medicine, 2006
- Loss of connexin 26 in mammary epithelium during early but not during late pregnancy results in unscheduled apoptosis and impaired developmentDevelopmental Biology, 2004