The incidence of MCI differs by subtype and is higher in men
- 31 January 2012
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 78 (5), 342-351
- https://doi.org/10.1212/wnl.0b013e3182452862
Abstract
Objective: Although incidence rates for mild cognitive impairment (MCI) have been reported, few studies were specifically designed to measure the incidence of MCI and its subtypes using published criteria. We estimated the incidence of amnestic MCI (aMCI) and nonamnestic MCI (naMCI) in men and women separately. Methods: A population-based prospective cohort of Olmsted County, MN, residents ages 70–89 years on October 1, 2004, underwent baseline and 15-month interval evaluations that included the Clinical Dementia Rating scale, a neurologic evaluation, and neuropsychological testing. A panel of examiners blinded to previous diagnoses reviewed data at each serial evaluation to assess cognitive status according to published criteria. Results: Among 1,450 subjects who were cognitively normal at baseline, 296 developed MCI. The age- and sex-standardized incidence rate of MCI was 63.6 (per 1,000 person-years) overall, and was higher in men (72.4) than women (57.3) and for aMCI (37.7) than naMCI (14.7). The incidence rate of aMCI was higher for men (43.9) than women (33.3), and for subjects with ≤12 years of education (42.6) than higher education (32.5). The risk of naMCI was also higher for men (20.0) than women (10.9) and for subjects with ≤12 years of education (20.3) than higher education (10.2). Conclusions: The incidence rates for MCI are substantial. Differences in incidence rates by clinical subtype and by sex suggest that risk factors for MCI should be investigated separately for aMCI and naMCI, and in men and women.This publication has 37 references indexed in Scilit:
- Use of a Medical Records Linkage System to Enumerate a Dynamic Population Over Time: The Rochester Epidemiology ProjectAmerican Journal of Epidemiology, 2011
- Prevalence of mild cognitive impairment is higher in menNeurology, 2010
- Effect of a Purpose in Life on Risk of Incident Alzheimer Disease and Mild Cognitive Impairment in Community-Dwelling Older PersonsArchives of General Psychiatry, 2010
- The APOE ε4 Allele Is Associated with Incident Mild Cognitive Impairment among Community-Dwelling Older PersonsNeuroepidemiology, 2009
- Validation of the Telephone Interview for Cognitive Status-modified in Subjects with Normal Cognition, Mild Cognitive Impairment, or DementiaNeuroepidemiology, 2009
- Prevalence of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Normal Cognitive AgingArchives of General Psychiatry, 2008
- Frequency and course of mild cognitive impairment in a multiethnic communityAnnals of Neurology, 2008
- The Mayo Clinic Study of Aging: Design and Sampling, Participation, Baseline Measures and Sample CharacteristicsNeuroepidemiology, 2008
- Transitions to Mild Cognitive Impairments, Dementia, and Death: Findings from the Nun StudyAmerican Journal of Epidemiology, 2007
- Estimating and Using Propensity Scores with Partially Missing DataJournal of the American Statistical Association, 2000