Lithium prevents grey matter atrophy in patients with bipolar disorder: an international multicenter study
- 27 January 2020
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 51 (7), 1201-1210
- https://doi.org/10.1017/s0033291719004112
Abstract
Background Lithium (Li) is the gold standard treatment for bipolar disorder (BD). However, its mechanisms of action remain unknown but include neurotrophic effects. We here investigated the influence of Li on cortical and local grey matter (GM) volumes in a large international sample of patients with BD and healthy controls (HC). Methods We analyzed high-resolution T1-weighted structural magnetic resonance imaging scans of 271 patients with BD type I (120 undergoing Li) and 316 HC. Cortical and local GM volumes were compared using voxel-wise approaches with voxel-based morphometry and SIENAX using FSL. We used multiple linear regression models to test the influence of Li on cortical and local GM volumes, taking into account potential confounding factors such as a history of alcohol misuse. Results Patients taking Li had greater cortical GM volume than patients without. Patients undergoing Li had greater regional GM volumes in the right middle frontal gyrus, the right anterior cingulate gyrus, and the left fusiform gyrus in comparison with patients not taking Li. Conclusions Our results in a large multicentric sample support the hypothesis that Li could exert neurotrophic and neuroprotective effects limiting pathological GM atrophy in key brain regions associated with BD.Keywords
This publication has 59 references indexed in Scilit:
- Neuroimaging and neurocognitive abnormalities associated with bipolar disorder in old ageInternational Journal of Geriatric Psychiatry, 2013
- Lithium, Gray Matter, and Magnetic Resonance Imaging SignalBiological Psychiatry, 2013
- Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013Bipolar Disorders, 2012
- A Comparison of Heritability Maps of Cortical Surface Area and Thickness and the Influence of Adjustment for Whole Brain Measures: A Magnetic Resonance Imaging Twin StudyTwin Research and Human Genetics, 2012
- Contrasting Effects of Haloperidol and Lithium on Rodent Brain Structure: A Magnetic Resonance Imaging Study with Postmortem ConfirmationBiological Psychiatry, 2012
- Lithium-Induced Gray Matter Volume Increase As a Neural Correlate of Treatment Response in Bipolar Disorder: A Longitudinal Brain Imaging StudyNeuropsychopharmacology, 2010
- Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studiesNeuroImage, 2009
- Gray and white matter brain volumes in older adults with bipolar disorderInternational Journal of Geriatric Psychiatry, 2009
- Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysisThe British Journal of Psychiatry, 2009
- No differential effect of age on brain matter volume and cognition in bipolar patients and healthy individualsBipolar Disorders, 2009