Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways
Open Access
- 1 January 2009
- journal article
- Published by Springer Science and Business Media LLC in Molecular Cancer
- Vol. 8 (1), 118
- https://doi.org/10.1186/1476-4598-8-118
Abstract
Osteosarcoma (OS) is the most common primary bone tumour in children and young adults. Despite improved prognosis, metastatic or relapsed OS remains largely incurable and no significant improvement has been observed in the last 20 years. Therefore, the search for alternative agents in OS is mandatory.This publication has 33 references indexed in Scilit:
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