Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men
Open Access
- 1 September 2013
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Vol. 305 (5), R490-R498
- https://doi.org/10.1152/ajpregu.00575.2012
Abstract
Obese individuals are characterized by low circulating adiponectin concentrations and an increased number of macrophages in adipose tissue, which is believed to be causally associated with chronic low-grade inflammation and insulin resistance. Regular physical exercise decreases overall morbidity in obese subjects, which may be due to modulations of inflammatory pathways. In this randomized clinical trial we investigated the separate effects of endurance training-induced weight loss, diet-induced weight loss, and endurance training per se (without weight loss) on plasma adiponectin multimer composition (Western blotting) and adipose tissue macrophage content (immunohistochemistry) in young, moderately overweight men. Weight loss and endurance training per se decreased whole body fat percentage in an additive manner. No intervention-induced changes were observed for plasma total adiponectin. Surprisingly, endurance training, irrespectively of any associated weight loss, shifted the adiponectin multimer distribution toward a lower molecular weight (21% decrease in HMW/LMW, P = 0.015), whereas diet-induced weight loss shifted the distribution toward a higher molecular weight (42% increase in HMW/MMW, P < 0.001). Furthermore, endurance training per se increased the number of anti-inflammatory CD163+macrophages [from 12.7 ± 2.1 (means ± SE) to 16.1 ± 3.1 CD163+cells/100 adipocytes, P = 0.013], whereas diet-induced weight loss tended to decrease CD68+macrophages in subcutaneous abdominal adipose tissue. Thus regular physical exercise influences systemic and adipose tissue inflammatory pathways differently than diet-induced weight loss in younger, moderately overweight men. Our data suggest that some of the health benefits of a physically active lifestyle may occur through modulations of anti- rather than pro-inflammatory pathways in young, overweight men.Keywords
This publication has 44 references indexed in Scilit:
- The Clinical Significance of the CD163+ and CD68+ Macrophages in Patients with Hepatocellular CarcinomaPLOS ONE, 2013
- Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+MacrophagesInternational Journal of Inflammation, 2013
- Effect of exercise training on chronic inflammationClinica Chimica Acta; International Journal of Clinical Chemistry, 2010
- Identification of Markers that Distinguish Monocyte-Derived Fibrocytes from Monocytes, Macrophages, and FibroblastsPLOS ONE, 2009
- Systemic Fate of the Adipocyte-Derived Factor AdiponectinDiabetes, 2009
- An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal womenClinical Science, 2007
- Adiponectin as an anti-inflammatory factorClinica Chimica Acta; International Journal of Clinical Chemistry, 2007
- Obesity induces a phenotypic switch in adipose tissue macrophage polarizationJCI Insight, 2007
- Impaired Multimerization of Human Adiponectin Mutants Associated with DiabetesOnline Journal of Public Health Informatics, 2003
- Alternative activation of macrophagesNature Reviews Immunology, 2003