The contribution of familial and heritable risks in heart failure
- 1 May 2007
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Cardiology
- Vol. 22 (3), 214-219
- https://doi.org/10.1097/hco.0b013e3280d9e855
Abstract
Purpose of review The purpose of this review is to summarize the recent literature regarding the familial heritability of heart failure and to discuss the possible mechanisms through which this risk is mediated. Recent findings Data from the Framingham Heart Study recently showed that the parental occurrence of heart failure increases the risk of heart failure in offspring. Although the mechanisms mediating this increased risk are not elucidated, heritable risks of heart failure may result from genes affecting the cardiac or vascular systems. Alternatively, familial risk may be mediated partly through the inheritance of recognized or as yet unidentified risk factors for heart failure. Heritable components or genetic loci for quantitative traits contribute to the development of hypertension, coronary artery disease, cardiomyopathies, valvular heart disease, and metabolic conditions, which collectively increase the risk of heart failure. Summary A careful assessment of the family history of heart failure and associated risk factors may identify treatable targets that can potentially reduce the likelihood of developing heart failure, and can assist in the implementation of preventive strategies for risk populations with stages A and B heart failure.Keywords
This publication has 89 references indexed in Scilit:
- The Genetic Bases of CardiomyopathiesJournal of the American College of Cardiology, 2006
- Association of Parental Heart Failure with Risk of Heart Failure in OffspringNew England Journal of Medicine, 2006
- Clinical and genetic issues in familial dilated cardiomyopathyJournal of the American College of Cardiology, 2005
- Lifetime Risk for Developing Congestive Heart FailureCirculation, 2002
- Obesity and the Risk of Heart FailureNew England Journal of Medicine, 2002
- Predictors of congestive heart failure in the elderly: the cardiovascular health studyJournal of the American College of Cardiology, 2000
- Profile for Estimating Risk of Heart FailureArchives of Internal Medicine, 1999
- Risk factors for heart failure in the elderly: a prospective community-based studyAmerican Journal Of Medicine, 1999
- Familial Dilated Cardiomyopathy: Cardiac Abnormalities Are Common in Asymptomatic Relatives and May Represent Early DiseaseJournal of the American College of Cardiology, 1998
- Survival after the onset of congestive heart failure in Framingham Heart Study subjects.Circulation, 1993