HowSaccharomyces cerevisiaecopes with toxic metals and metalloids
Open Access
- 1 November 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in FEMS Microbiology Reviews
- Vol. 34 (6), 925-951
- https://doi.org/10.1111/j.1574-6976.2010.00217.x
Abstract
Toxic metals and metalloids are widespread in nature and can locally reach fairly high concentrations. To ensure cellular protection and survival in such environments, all organisms possess systems to evade toxicity and acquire tolerance. This review provides an overview of the molecular mechanisms that contribute to metal toxicity, detoxification and tolerance acquisition in budding yeast Saccharomyces cerevisiae. We mainly focus on the metals/metalloids arsenic, cadmium, antimony, mercury, chromium and selenium, and emphasize recent findings on sensing and signalling mechanisms and on the regulation of tolerance and detoxification systems that safeguard cellular and genetic integrity.This publication has 203 references indexed in Scilit:
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