Predictors of freezing in Parkinson's disease: A survey of 6,620 patients
- 20 March 2007
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 22 (7), 953-956
- https://doi.org/10.1002/mds.21458
Abstract
Data from a survey of 6,620 Parkinson's disease patients were examined for correlation of freezing with age, sex, duration, subjective severity of Parkinson's disease, and antiparkinsonian medication. Forty-seven percent of the patients reported experiencing freezing regularly. Logistic regression analysis showed that freezing was significantly associated with a longer disease duration and a more advanced stage of the disease. Freezing episodes were more likely in men than in women and in patients taking, in addition to levodopa, Entacapone, Amantadine, or dopamine agonists. Finally, patients considering tremor as their main symptom reported freezing less frequently. Common antiparkinsonian drugs given in combination with levodopa were not negatively correlated with freezing. The results underline the necessity to develop appropriate countermeasures against this phenomenon, which is widely known to cause significant impairment of patients' quality of life and—as our data also showed—may cause traffic accidents in licensed patients. © 2007 Movement Disorder SocietyThis publication has 15 references indexed in Scilit:
- Pharmacotherapy of Parkinson’s disease in GermanyZeitschrift für Neurologie, 2005
- Driving in Parkinson's disease: Mobility, accidents, and sudden onset of sleep at the wheelMovement Disorders, 2005
- Predictors of sudden onset of sleep in Parkinson's diseaseMovement Disorders, 2004
- Falls and freezing of gait in Parkinson's disease: A review of two interconnected, episodic phenomenaMovement Disorders, 2004
- Zusammenhang zwischen selbstberichteter Tagesmudigkeit und selbstberichteten Schlafstorungen vor und nach einer Erkrankung an M. Parkinson - Fragebogendaten von 6620 Parkinson-Patienten. Correlation of Self-Reported Daytime Sleepiness and Self-Reported Sleep Disorders Before and After the Onset of Parkinson's Disease (PD) - Data from a Questionnaire Survey of 6,620 PD PatientsSomnologie - Schlafforschung und Schlafmedizin, 2003
- Freezing of gait in patients with advanced Parkinson's diseaseJournal of Neural Transmission, 2001
- Falling asleep at the wheel: Motor vehicle mishaps in persons taking pramipexole and ropiniroleNeurology, 1999
- Freezing phenomenon in patients with parkinsonian syndromesMovement Disorders, 1997
- Motor blocks in Parkinson's diseaseNeurology, 1992
- ParkinsonismNeurology, 1967