Induction of Ovulation and Fertility in Amenorrheic Women by Pulsatile Low-Dose Gonadotropin-Releasing Hormone
- 26 April 1984
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 310 (17), 1069-1074
- https://doi.org/10.1056/nejm198404263101702
Abstract
In functional hypothalamic amenorrhea, failure of ovulation probably results from deficient hypothalamic secretion of gonadotropin-releasing hormone (GnRH). We treated 14 infertile women in whom this condition was resistant to clomiphene with pulses of 5 to 15 μg of GnRH administered subcutaneously by portable pumps at 90-minute intervals in 36 cycles of treatment.Keywords
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