Asymmetric Synthesis of the Carbocyclic Nucleoside Building Block (R)-(+)-4-Aminocyclopentenone Using δ-Amino β-Ketophosphonates and Ring-Closing Metathesis (RCM)
- 17 March 2004
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (8), 1269-1272
- https://doi.org/10.1021/ol049795v
Abstract
Amino keto-2,7-dienes undergo ring-closing metathesis (RCM) to give 4-aminocyclopentenones, valuable intermediates in the asymmetric construction of carbocyclic nucleosides. The key amino ketodienes were prepared using delta-amino beta-ketophophonates, a new sulfinimine-derived chiral building block, and HWE chemistry. [reaction: see text]Keywords
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