The Rabbit(Oryctolagus cuniculus):A Model for Mammalian Reproduction and Early Embryology

Abstract

INTRODUCTION: The rabbit is a valuable animal model for a variety of biomedical research areas including in vitro fertilization, early embryology and organogenesis, neurophysiology, ophthalmology, and cardiovascular research. The rabbit is also used as a model for toxicology studies and analyses of drug effects on embryo and fetal development, as well as for research involving the immune system (e.g., host/pathogen interactions, asthma, arthritis, systemic lupus erythematosus). The rabbit’s most prominent use as a laboratory animal is antibody production; most biomedical research institutions thus provide the infrastructure and veterinary expertise for keeping rabbits. This article discusses current advances in applying modern life science research methods to basic and applied embryological research using the rabbit as a model for early intrauterine development in mammals, including state-of-the-art genomic tools and the sequencing data available (and planned) for the rabbit.