Mechanism of the resistance to cytotoxicity which precedes aflatoxin B1 hepatocarcinogenesis

Abstract

In vivo there is evidence for a decreased covalent binding of aflatoxin B ₁ to DNA following low-level feeding with the toxin. It is suggested that this is due to increased detoxification of aflatoxin B ₁ by conjugation with reduced glutathione. Evidence indicating increased levels of reduced glutathione and glutathione S-trans-ferase activity are presented.