Increasing populations of glyphosate-resistant Palmer amaranth [Amaranthus palmeri (S.) Wats.] have increased weed management costs for Texas High Plains cotton [Gossypium hirsutum (L.)] producers. The introduction of dicamba-tolerant cotton varieties and registration of dicamba formulations for postemergence use, combined with residual herbicides, can effectively control Palmer amaranth. Field studies were conducted in 2018 and 2019 near Lubbock, TX, USA to evaluate Palmer amaranth control and economics of weed management in dicamba-, glufosinate-, glyphosate-, and conventional cotton systems. The most consistent season-long Palmer amaranth control was achieved with the dicamba-tolerant system in both years. In 2018, greatest lint yields were achieved with dicamba-tolerant system when compared to the conventional and glufosinate-tolerant systems. In 2018, greatest gross margin above weed management costs were achieved with the dicamba-tolerant and glyphosate-tolerant systems. Greatest lint yield was achieved with the dicamba-tolerant and conventional systems in 2019 and greatest gross margins were achieved with the dicamba-tolerant system. Total variable costs were similar across all systems, with greater seed/technology and herbicide costs in dicamba-tolerant and glufosinate-tolerant systems, compared to higher tillage and hand hoeing costs in glyphosate-tolerant and conventional systems.