Seroepidemiologic Studies of Infectious Mononucleosis with Eb Virus
- 21 November 1968
- journal article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 279 (21), 1121-1127
- https://doi.org/10.1056/nejm196811212792101
Abstract
Certain epidemiologic features of infectious mononucleosis are indicated by antibody patterns to the EB or herpes-like virus of Burkitt lymphoma. The absence of antibody correlated well with susceptibility: of 268 entering college students whose serums lacked EBV antibody, infectious mononucleosis developed in 15 per cent; in 94 whose serums already contained antibody, none had clinical disease. EBV antibody also correlated well with heterophil antibody; EBV antibody was present in the serums of all 135 patients who had heterophil-antibody-positive infectious mononucleosis and also in six with clinically and hematologically typical cases whose serums were persistently heterophil-antibody negative, suggesting that EB virus may be associated with both forms of illness. In a third group of patients clinical features resembled infectious mononucleosis, but the serums contained neither heterophil nor EBV antibodies. At present, EB virus is strongly implicated as a cause of infectious mononucleosis.Keywords
This publication has 10 references indexed in Scilit:
- Infectious Mononucleosis: Complement-Fixing Antibodies to Herpes-Like Virus Associated with Burkitt LymphomaScience, 1968
- Infectious mononucleosis: detection of herpeslike virus and reticular aggregates of small cytoplasmic particles in continuous lymphoid cell lines derived from peripheral blood.Proceedings of the National Academy of Sciences of the United States of America, 1968
- Infectious mononucleosis. Clinical manifestations in relation to EB virus antibodiesJAMA, 1968
- Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis.Proceedings of the National Academy of Sciences of the United States of America, 1968
- Culture of normal human leukocytesJAMA, 1967
- CYTOMEGALOVIRUS MONONUCLEOSIS WITH JAUNDICE AS PRESENTING SIGNThe Lancet, 1966
- Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis.BMJ, 1965
- The Incubation Period of Infectious MononucleosisAmerican Journal of Public Health and the Nations Health, 1964
- Toxoplasmosis and Infectious MononucleosisArchives of Internal Medicine, 1962
- Viremia and Viruria in Adenovirus InfectionsThe New England Journal of Medicine, 1961