The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing
Open Access
- 17 June 2009
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in RNA
- Vol. 15 (8), 1433-1442
- https://doi.org/10.1261/rna.1703809
Abstract
GW182 family proteins interact directly with Argonaute proteins and are required for miRNA-mediated gene silencing in animal cells. The domains of the GW182 proteins have recently been studied to determine their role in silencing. These studies revealed that the middle and C-terminal regions function as an autonomous domain with a repressive function that is independent of both the interaction with Argonaute proteins and of P-body localization. Such findings reinforce the idea that GW182 proteins are key components of miRNA repressor complexes in metazoa.Keywords
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