Variations in theNRAMP1Gene and Susceptibility to Tuberculosis in West Africans
Open Access
- 5 March 1998
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 338 (10), 640-644
- https://doi.org/10.1056/nejm199803053381002
Abstract
Genetic factors may affect the susceptibility to tuberculosis, but no specific genes governing susceptibility have been identified. In mice, natural resistance to infection with some mycobacteria is influenced by the gene for natural-resistance–associated macrophage protein 1 (Nramp1 ), but the role of the human homologue of this gene, NRAMP1, in tuberculosis is unknown. We typed polymorphisms in NRAMP1 in a case–control study of tuberculosis in the Gambia, West Africa.This publication has 21 references indexed in Scilit:
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