Production of Lantipeptides in Escherichia coli
Open Access
- 29 November 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 133 (8), 2338-2341
- https://doi.org/10.1021/ja109044r
Abstract
Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links. We describe the preparation of seven different lantipeptides in Escherichia coli and demonstrate that this methodology can be used to incorporate nonproteinogenic amino acids.Keywords
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