NHANES III
Open Access
- 1 September 2007
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American Society of Nephrology
- Vol. 18 (9), 2575-2582
- https://doi.org/10.1681/asn.2006121411
Abstract
Whether the creatinine-based glomerular filtration rate (GFR) thresholds used to define chronic kidney disease (CKD) identify metabolic abnormalities similarly in minority and nonminority populations is unknown. We addressed this question among adult participants in the Third National Health and Nutrition Examination Survey (NHANES III) (n = 15,837). GFR was estimated from serum creatinine values and metabolic abnormalities were defined by 5th or 95th percentile values. After adjustment for age, demographic characteristics, and GFR, black participants were significantly more likely than white participants to have abnormal levels of systolic and diastolic blood pressure, hemoglobin, phosphorus, and uric acid. Hispanic subjects were significantly more likely to have abnormal levels of systolic blood pressure, hemoglobin, bicarbonate, and phosphorus. Among participants with GFR < 60 mL/min per 1.73 m2, black participants were significantly more likely to have abnormal levels of systolic and diastolic blood pressure, hemoglobin, and uric acid; Hispanic subjects were significantly more likely to have abnormal systolic blood pressure levels. Metabolic abnormalities were more common in minority populations, and low GFR appeared to have a multiplicative effect. Defining CKD using a single GFR threshold may be disadvantageous for minority populations because metabolic abnormalities are present at higher levels of GFR.Keywords
This publication has 24 references indexed in Scilit:
- Racial Differences in the Prevalence of Chronic Kidney Disease among Participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort StudyJournal of the American Society of Nephrology, 2006
- Chronic Kidney Disease Awareness, Prevalence, and Trends among U.S. Adults, 1999 to 2000Journal of the American Society of Nephrology, 2005
- Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and HospitalizationNew England Journal of Medicine, 2004
- Racial differences in potassium disposalKidney International, 2004
- Editorial boardAmerican Journal of Kidney Diseases, 2003
- Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn StudyKidney International, 2002
- Racial differences in the incidence of end‐stage renal diseaseEthnicity & Health, 1996
- Race and sex differences in erythrocyte Na+, K+, and Na+-K+-adenosine triphosphatase.JCI Insight, 1985
- Cardiovascular and humoral responses to extremes of sodium intake in normal black and white men.Circulation, 1979
- RACIAL FACTORS IN THE INCIDENCE AND CAUSATION OF END-STAGE RENAL DISEASE (ESRD)ASAIO Journal, 1977