The Metabolic Coupling of Arginine Metabolism to Nitric Oxide Generation by Astrocytes
- 1 May 2006
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 8 (5-6), 919-928
- https://doi.org/10.1089/ars.2006.8.919
Abstract
Arginine, the only known precursor of nitric oxide, enters the brain parenchyma from the blood through the endothelial cells or from the cerebral spinal fluid through the ependymal cells. Astrocytes, whose processes abut the endothelium and ependymum, take up arginine through cationic amino acid transporters and release arginine through this transport system to the synapses that astrocytes shield. Some of these synapses are excitatory, and liberate glutamate into the synaptic cleft. Glutamate induces arginine release from astrocytes, making it available to the neuron. Neurons can take up arginine to be used in nitric oxide-mediated processes, such as neurotransmission. Thus, neural and nonneural cells act in concert to affect neuron physiology in an elegantly integrated system. This review focuses on the components of the interaction between astrocytes and neurons in nitric oxide biology.Keywords
This publication has 88 references indexed in Scilit:
- Arginine release from rat cerebellar astrocytes: autocrine roles for glutamate and nitric oxide?Neuroscience Letters, 2004
- Arginine Availability Controls the N-Methyl-d-Aspartate-Induced Nitric Oxide Synthesis: Involvement of a Glial-Neuronal Arginine TransferJournal of Neurochemistry, 2002
- Peroxynitrite Stimulates l-Arginine Transport Systemy+ in Glial CellsPublished by Elsevier BV ,2002
- Peroxynitrite Anion Stimulates Arginine Release from Cultured Rat AstrocytesJournal of Neurochemistry, 2002
- Regulation of Nitric Oxide Production by Arginine Metabolic EnzymesBiochemical and Biophysical Research Communications, 2000
- Biological effects of arginine metabolitesActa Physiologica Scandinavica, 2000
- Nitric Oxide Inhibits Ornithine Decarboxylase by S-NitrosylationBiochemical and Biophysical Research Communications, 1999
- Characterization of l‐Arginine and Aminoguanidine Uptake into Isolated Rat Choroid Plexus: Differences in Uptake Mechanisms and Inhibition by Nitric Oxide Synthase InhibitorsJournal of Neurochemistry, 1995
- Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.JCI Insight, 1994
- Mechanism of Spermidine Uptake in Cultured Mammalian Cells and Its Inhibition by Some Polyamine AnaloguesPathobiology, 1990