Density of CD163+CD11c+ Dendritic Cells Increases and CD103+ Dendritic Cells Decreases in the Coeliac Lesion
- 6 July 2011
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 74 (2), 186-194
- https://doi.org/10.1111/j.1365-3083.2011.02549.x
Abstract
Coeliac disease is a chronic inflammation of the intestinal mucosa controlled by gluten-specific T cells restricted by disease-associated HLA-DQ molecules. We have previously reported that mucosal CD11c(+) dendritic cells (DCs) are responsible for activation of gluten-reactive T cells within the coeliac lesion. In mice, intestinal CD11c(+) DCs comprise several functionally distinct subsets. Here, we report that HLA-DQ(+) antigen-presenting cells (APCs) in normal human duodenal mucosa can be divided into four subsets with striking similarities to those described in mice: CD163(+) CD11c(-) macrophages (74%), and CD11c(+) cells expressing either CD163 (7%), CD103 (11%) or CD1c (13%). CD103(+) and CD1c(+) DCs belonged to partly overlapping populations, whereas CD163(+) CD11c(+) APCs appeared to be a distinct population. In the coeliac lesion, we found increased density of CD163(+) CD11c(+) APCs, whereas the density of CD103(+) and CD1c(+) DCs was decreased, suggesting that distinct subpopulations of APCs in coeliac disease may exert different functions in the pathogenesis.Keywords
This publication has 35 references indexed in Scilit:
- Found in translation: the human equivalent of mouse CD8+ dendritic cellsThe Journal of Experimental Medicine, 2010
- Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cellsThe Journal of Experimental Medicine, 2010
- The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+ dendritic cellsThe Journal of Experimental Medicine, 2010
- Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cellsThe Journal of Experimental Medicine, 2010
- Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functionsThe Journal of Experimental Medicine, 2009
- Origin of the Lamina Propria Dendritic Cell NetworkImmunity, 2009
- Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humansThe Journal of Experimental Medicine, 2008
- Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responsesNature Immunology, 2007
- A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanismThe Journal of Experimental Medicine, 2007
- Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patientsProceedings of the National Academy of Sciences of the United States of America, 2007