The application of wavelet denoising to infrared spectra was investigated. Six different wavelet denoising methods (SURE, VISU, HYBRID, MINMAX, MAD and WAVELET PACKETS) were applied to pure infrared spectra with various added levels of homo- and heteroscedastic noise. The performances of the wavelet denoising methods were compared with the standard Fourier and moving mean filtering in terms of root mean square errors between the pure and denoised spectra and visual quality of the denoised spectrum. The use of predictive ability as a possible objective criterion for denoising performance was also investigated. The main conclusion is that for very low signal-to-noise ratios (S/N) the standard denoising methods (Fourier and moving mean) are comparable to the more sophisticated methods. At higher S/N levels the wavelet denoising methods, in particular the HYBRID and VISU methods, are better. Wavelet methods are also better in restoring the visual quality of the denoised infrared spectra.