RNA Editing AIDs Antibody Diversification?
- 8 September 2000
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 289 (5485), 1705-1706
- https://doi.org/10.1126/science.289.5485.1705
Abstract
How do B cells generate the enormous diversity of antibodies that are able to recognize and bind to whichever antigen a B cell might happen to encounter in the body? Several genetic mechanisms that manipulate different combinations of immunoglobulin genes are known. In their Perspective, Neuberger and Scott, highlight another genetic mechanism called RNA editing now shown to be involved in the production of antibody diversity.Keywords
This publication has 6 references indexed in Scilit:
- Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing EnzymeCell, 2000
- Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)Cell, 2000
- Purification and Molecular Cloning of a Novel Essential Component of the Apolipoprotein B mRNA Editing Enzyme-ComplexJournal of Biological Chemistry, 2000
- Molecular Cloning of Apobec-1 Complementation Factor, a Novel RNA-Binding Protein Involved in the Editing of Apolipoprotein B mRNAMolecular and Cellular Biology, 2000
- Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutationThe EMBO Journal, 1999
- Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B CellsJournal of Biological Chemistry, 1999