Strontium-89 chloride for pain palliation in prostatic skeletal malignancy
- 9 September 1991
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 64 (765), 816-822
- https://doi.org/10.1259/0007-1285-64-765-816
Abstract
In a multi-centre study strontium-89 was shown to be effective in relieving bone pain from prostatic carcinoma in patients who had failed conventional therapies. Of 83 patients assessed at 3 months, following the administration of a dose of at least 1.5 MBq/kg, 75% derived benefit and 22% became pain free. Symptomatic improvement usually occurred within 6 weeks and continued for between 4 and 15 months (mean 6 months). Based on the dose estimation part of this study the recommended dose of strontium-89 is 150 MBq. Toxicity was low, provided platelet levels were above 100 x 10(9) l-1 at the time of treatment. Repeat treatments with strontium-89 may be given at intervals of not less than 3 months. Strontium-89 is administered intravenously on an out-patient basis with no special radiological protection precautions.Keywords
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