SlC30A8 Is a Major Target of Humoral Autoimmunity in Type 1 Diabetes and a Predictive Marker in Prediabetes
- 15 December 2008
- journal article
- research article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1150 (1), 256-259
- https://doi.org/10.1196/annals.1447.029
Abstract
Type 1A diabetes (T1D) results from autoimmunity targeted at a limited number of molecules that are expressed in the pancreatic β cell. Putative novel autoantigen candidates were identified from microarray expression profiling of human and rodent islet cells. The highest ranking candidate was Slc30A8 (zinc transporter 8; ZnT8), which was screened by radioimmunoprecipitation assays against new‐onset T1D and prediabetic sera. Such assays detected 63% of subjects with new‐onset diabetes, but fewer than 2% of controls, 3% of those with type 2 diabetes, and 10% of patients with other autoimmune disorders. ZnT8 autoantibodies were found, however, in 26% of T1D subjects previously classified as autoantibody‐negative on the basis of existing markers (GADA, IA2 A, IAA, and ICA). We conclude that SLC30A8 provides an important additional and independent predictive marker for T1D.Keywords
This publication has 6 references indexed in Scilit:
- Invasion of the killer B's in type 1 diabetesFrontiers in Bioscience-Landmark, 2007
- Type 1 diabetes: pathogenesis and preventionCMAJ : Canadian Medical Association Journal, 2006
- Autoantibodies in DiabetesDiabetes, 2005
- Development of Type 1 Diabetes despite Severe Hereditary B-Cell DeficiencyThe New England Journal of Medicine, 2001
- Islet Cell Antibodies Represent Autoimmune Response Against Several AntigensInternational Journal of Experimental Diabetes Research, 2001
- Beta-Cell Autoantibodies in Infants and Toddlers without IDDM Relatives: Diabetes Autoimmunity Study in the Young (DAISY)Journal of Autoimmunity, 1996