Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
Top Cited Papers
- 1 March 2010
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 91 (3), 535-546
- https://doi.org/10.3945/ajcn.2009.27725
Abstract
Background: A reduction in dietary saturated fat has generally been thought to improve cardiovascular health. Objective: The objective of this meta-analysis was to summarize the evidence related to the association of dietary saturated fat with risk of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD; CHD inclusive of stroke) in prospective epidemiologic studies. Design: Twenty-one studies identified by searching MEDLINE and EMBASE databases and secondary referencing qualified for inclusion in this study. A random-effects model was used to derive composite relative risk estimates for CHD, stroke, and CVD. Results: During 5–23 y of follow-up of 347,747 subjects, 11,006 developed CHD or stroke. Intake of saturated fat was not associated with an increased risk of CHD, stroke, or CVD. The pooled relative risk estimates that compared extreme quantiles of saturated fat intake were 1.07 (95% CI: 0.96, 1.19; P = 0.22) for CHD, 0.81 (95% CI: 0.62, 1.05; P = 0.11) for stroke, and 1.00 (95% CI: 0.89, 1.11; P = 0.95) for CVD. Consideration of age, sex, and study quality did not change the results. Conclusions: A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat.This publication has 50 references indexed in Scilit:
- Saturated fat, carbohydrate, and cardiovascular diseaseThe American Journal of Clinical Nutrition, 2010
- Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studiesThe American Journal of Clinical Nutrition, 2009
- Dietary Total Fat Intake and Ischemic Stroke Risk: The Northern Manhattan StudyNeuroepidemiology, 2009
- Sex Differences of Endogenous Sex Hormones and Risk of Type 2 DiabetesJama-Journal Of The American Medical Association, 2006
- Dietary Fat and Risk of Coronary Heart Disease: Possible Effect Modification by Gender and AgeAmerican Journal of Epidemiology, 2004
- Animal Protein, Animal Fat, and Cholesterol Intakes and Risk of Cerebral Infarction Mortality in the Adult Health StudyStroke, 2004
- Diet and 20-Year Mortality from Coronary Heart DiseaseThe New England Journal of Medicine, 1985
- Diet, Serum Cholesterol, and Death from Coronary Heart DiseaseThe New England Journal of Medicine, 1981
- The Oslo Diet-Heart StudyCirculation, 1970
- A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of AtherosclerosisCirculation, 1969