Genome Sequence of a Novel HIV-1 Circulating Recombinant Form 54_01B from Malaysia
- 15 October 2012
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 86 (20), 11405-11406
- https://doi.org/10.1128/jvi.01949-12
Abstract
We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B′ and CRF01_AE, with identical recombination breakpoints observed in the gag , pol , and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B′ and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.Keywords
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