Prediction of Drug Response and Safety in Clinical Practice
- 8 December 2011
- journal article
- Published by Springer Science and Business Media LLC in Journal of Medical Toxicology
- Vol. 8 (1), 43-51
- https://doi.org/10.1007/s13181-011-0198-7
Abstract
Many clinicians hoped that the completion of the Human Genome Project would result in "individualized drug therapy," i.e., determining the right medication at the right dose 100% of the time based upon the individual's genetics. The pharmacogenomic prediction of drug efficacy and safety has not become a reality due to continuing realization of the complexity dictating the human-drug interaction. New methods of metabolomics, proteomics, and transcriptomics that account for this complexity hold promise for translational researchers hoping to increase drug efficacy and decrease drug toxicity.Keywords
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