Long-term Outcome in Children After Henoch-Schönlein Purpura Nephritis
- 1 July 2007
- journal article
- Published by SAGE Publications in Clinical Pediatrics
- Vol. 46 (6), 505-511
- https://doi.org/10.1177/0009922806298896
Abstract
This study investigated predictors of renal survival in children with Henoch-Schönlein purpura glomerulonephritis. Records of patients with Henoch-Schönlein purpura glomerulonephritis evaluated at our center, from 1953-1990, were reviewed. Data were abstracted from records of patients seen within 5 years. Others were mailed a questionnaire or contacted by telephone. Primary outcome measures were renal survival and presence of urinary abnormalities or hypertension. Of the 65 eligible patients with Henoch Schönlein purpura glomerulonephritis, follow-up data was obtainable for 81.5%. The median follow-up was 20 years. At last follow-up, 66% of patients had normal renal function and urinalyses, and 21% had progressed to end-stage renal disease. The only factor associated with the development of end-stage renal disease was the use of cytotoxic agents. There are no features at initial presentation that identify children at risk of disease progression. Close follow-up of all children with Henoch Schönlein purpura glomerulonephritis is warranted.Keywords
This publication has 13 references indexed in Scilit:
- The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and AdolescentsPediatrics, 2004
- Cyclosporin A for the treatment of severe Henoch-Schönlein glomerulonephritisPediatric Nephrology, 2003
- Henoch-Schönlein Purpura in Children: Report of 100 Patients and Review of the LiteratureMedicine, 1999
- Methylprednisolone pulse therapy in the treatment of severe forms of Schönlein-Henoch purpura nephritisPediatric Nephrology, 1998
- Long-term follow-up of childhood Henoch-Schönlein nephritisThe Lancet, 1992
- The American College of Rheumatology 1990 criteria for the classification of henoch‐schönlein purpuraArthritis & Rheumatism, 1990
- Long term renal prognosis of Henoch-Schönlein Purpura in an unselected childhood populationEuropean Journal of Pediatrics, 1988
- The Use of Plasma Creatinine Concentration for Estimating Glomerular Filtration Rate in Infants, Children, and AdolescentsPediatric Clinics of North America, 1987
- Prognostic Significance of Urinary Findings and Renal Biopsies in Children with Henoch-Schönlein NephritisClinical Pediatrics, 1986
- Henoch-Schonlein nephritis: long-term prognosis of unselected patients.Archives of Disease in Childhood, 1981