Use of the Proposals of the International Association for the Study of Lung Cancer in the Forthcoming Edition of Lung Cancer Staging System to Predict Long-Term Prognosis of Operated Patients
- 1 March 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Cancer Journal
- Vol. 16 (2), 176-181
- https://doi.org/10.1097/ppo.0b013e3181ce474e
Abstract
To evaluate the utility of the proposals of the International Association for the Study of Lung Cancer (IASLC) in the forthcoming 7th edition of lung cancer staging system to classify patients submitted to radical surgical resection of non-small cell lung cancer and to compare their value in predicting long-term prognosis with the existing 6th edition of the American Joint Committee on Cancer (AJCC)/Union Internationale Contre le Cancer (UICC) TNM classification.Nine hundred twenty-one patients received an anatomic resection and hilar-mediastinal dissection for primary non-small cell lung cancer during the period 1990 to 2005. Histopathologic staging following the actual AJCC/UICC TNM classification were as follows: 207 T1, 562 T2, 148 T3, and 4 T4; 570 N0, 149 N1, 198 N2, and 4 N3; 163 stage IA, 346 IB, 23 IIA, 157 IIB, 224 IIIA, and 8 IIIB. Stages reclassified using the proposals of IASLC for the new staging system were as follows: 101 T1a, 106 T1b, 400 T2a, 103 T2b, 210 T3, and 1 T4; 163 stage IA, 262 IB, 157 IIA, 106 IIB, 230 IIIA, and 4 IIIB.Follow-up was obtained for 836 patients. Mean follow-up was 46.5 +/- 48.9 months. N-status (unchanged between the 2 classifications) was confirmed to be a significant prognostic factor. Significant differences in 10-year disease-related survival were demonstrated between stages IIB and IIIA only (35% vs 14%) of the AJCC/UICC TNM classification and between stages IB and IIA (60% vs 46%) and stages IIB and IIIA (39% vs 15%) of the IASLC proposals for a new classification.The proposals of IASLC in the forthcoming 7th edition of the lung cancer staging system are demonstrated to be better able to separate prognostically distinct groups of patients operated for non-small cell lung cancer than the accepted existing 6th AJCC/UICC TNM classification.Keywords
This publication has 10 references indexed in Scilit:
- The IASLC Lung Cancer Staging Project: Proposals for the Revision of the TNM Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification of Malignant TumoursJournal of Thoracic Oncology, 2007
- The IASLC Lung Cancer Staging Project: Proposals for the Revision of the N Descriptors in the Forthcoming Seventh Edition of the TNM Classification for Lung CancerJournal of Thoracic Oncology, 2007
- The IASLC Lung Cancer Staging Project: Proposals for the Revision of the T Descriptors in the Forthcoming (Seventh) Edition of the TNM Classification for Lung CancerJournal of Thoracic Oncology, 2007
- How should the TNM staging system for lung cancer be revised? A simulation based on the Japanese Lung Cancer Registry populationsThe Journal of Thoracic and Cardiovascular Surgery, 2006
- Lung Cancer Staging: A Case for a New T DefinitionThe Annals of Thoracic Surgery, 2006
- The International Association for the Study of Lung Cancer International Staging Project on Lung CancerJournal of Thoracic Oncology, 2006
- Impact of Large Tumor Size on Survival After Resection of Pathologically Node Negative (pN0) Non–Small Cell Lung CancerThe Annals of Thoracic Surgery, 2005
- T2 tumors larger than five centimeters in diameter can be upgraded to T3 in non–small cell lung cancerThe Journal of Thoracic and Cardiovascular Surgery, 2001
- Revisions in the International System for Staging Lung CancerSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1997
- Surgical Results and Prognostic Factors in Early Non–Small Cell Lung CancerThe Annals of Thoracic Surgery, 1997