Capsaicin Pre-treatment Provides Neurovascular Protection Against Neonatal Hypoxic-Ischemic Brain Injury in Rats
- 24 May 2011
- book chapter
- other
- Published by Springer Science and Business Media LLC
- Vol. 111, 225-230
- https://doi.org/10.1007/978-3-7091-0693-8_38
Abstract
Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia. Accordingly, in this study, we investigated the way in which capsaicin-mediated TRPV1 modulation could attenuate damage in an experimental hypoxic-ischemic (HI) neonatal brain injury model. The Rice-Vannucci method was used in 10-day-old rat pups by performing unilateral carotid artery ligation followed by 2 h of hypoxia (8% O2 at 37°C). Capsaicin was administered intraperitoneally (0.2 mg/kg or 2.0 mg/kg) at 3 h pre-HI or 1 h post-HI. Post assessment included measurement of infarction volume at 24 and 72 h in addition to an assessment of the vascular dynamics of the middle cerebral artery (MCA) at 6 h post-HI. The results indicated that pre-treatment with capsaicin reduced infarction volume significantly with either low-dose or high-dose treatment. Pre-treatment also improved myogenic tone and decreased apoptotic changes in the distal MCA. We concluded that capsaicin pre-treatment may provide neurovascular protection against neonatal HI.Keywords
This publication has 14 references indexed in Scilit:
- Periventricular white matter damage in the hypoxic neonatal brain: Role of microglial cellsProgress in Neurobiology, 2009
- Transient receptor potential ion channels as participants in thermosensation and thermoregulationAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2007
- The Timing of Neonatal Brain DamageNeonatology, 2006
- Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brainNeuroscience, 2006
- Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbilsBritish Journal of Pharmacology, 2005
- Vanilloid Receptor TRPV1, Sensory C-Fibers, and Vascular AutoregulationCirculation Research, 2004
- Reperfusion Differentially Induces Caspase-3 Activation in Ischemic Core and Penumbra After Stroke in Immature BrainStroke, 2003
- Neurodegeneration in the Thalamus following Neonatal Hypoxia-Ischemia Is Programmed Cell DeathDevelopmental Neuroscience, 2001
- Cloning and functional expression of a human orthologue of rat vanilloid receptor-1Pain, 2000
- Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and humanProceedings of the National Academy of Sciences of the United States of America, 2000