Bilateral Anterior Uveitis: A Feature of Streptokinase-Induced Serum Sickness

Abstract

Streptokinase is a commonly used thrombolytic agent. An unusual but well-documented adverse reaction is serum sickness¹. Serum sickness typically develops one to two weeks after exposure to an antigen, with manifestations ranging from asymptomatic cutaneous eruptions to severe conditions such as glomerulonephritis, vasculitis, or pericarditis. Other features include fever, arthralgias, albuminuria, lymphadenopathy, and dependent edema. The condition usually resolves after withdrawal of the causative agent, but systemic corticosteroid therapy may be indicated if end-organ damage is severe. We report a case of serum sickness in which uveitis was a presenting feature.