Amplified Peroxidase‐like Activity of Co2+ Using 8‐Hydroxyquinoline and Its Application for Ultrasensitive Colorimetric Detection of Clioquinol
- 3 October 2021
- journal article
- research article
- Published by Wiley in Chemistry – An Asian Journal
- Vol. 16 (23), 3957-3962
- https://doi.org/10.1002/asia.202100997
Abstract
8-hydroxyquinoline (8HQ) and its derivatives display diverse bioactivities and therapeutic potentials. In this study, we unveiled that 8HQ can boost the peroxidase-like activity of Co2+ in the presence of bicarbonate (HCO3-) in neutral pH at room temperature. With 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS) as the substrate, the formed Co2+/8HQ/HCO3- complex shows robust catalytic activity with the turnover number (kcat) tens to hundreds of times higher than that of Co3O4 and other Co2+ complexes in terms of per cobalt ion. This system was used to design colorimetric sensors for ultrasensitive detection of 8HQ-based drugs by activating the activity of Co2+. Take detecting clioquinol as an example, a detection limit of 2.4 nM clioquinol with a linear range from 0.01 to 0.2 μM was obtained. This work not only revealed a new kind of ligand that activated the activity of Co2+, but also provided a facile, low-cost, ultrasensitive, easy-to-use, and universal strategy for sensing various 8HQ-based drugs. Further development of this catalytic system might benefit to overcome drug resistance by combined medication.Keywords
Funding Information
- Natural Science Foundation of Shandong Province (ZR2019BB047)
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