A Phosphoramidite-Based Synthesis of Phosphoramidate Amino Acid Diesters of Antiviral Nucleosides
- 1 September 1994
- journal article
- research article
- Published by Taylor & Francis Ltd in Nucleosides and Nucleotides
- Vol. 13 (9), 1891-1903
- https://doi.org/10.1080/15257779408010671
Abstract
A general synthetic procedure is presented for the preparation of 5′-amino acid phosphoramidates of zidovudine (AZT), 3′-deoxy-2′,3′-didehydrothymidine (D4T), and 3′-fluoro-3′-deoxythymidine (FLT) from their corresponding phosphoramidites. These water soluble amino acid phosphoramidates are more non-polar than the parent nucleoside and exhibit high stability in aqueous media.Keywords
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