Targeted PARACEST nanoparticle contrast agent for the detection of fibrin
Open Access
- 6 November 2006
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 56 (6), 1384-1388
- https://doi.org/10.1002/mrm.21093
Abstract
A lipid‐encapsulated perfluorocarbon nanoparticle molecular imaging contrast agent that utilizes a paramagnetic chemical exchange saturation transfer (PARACEST) chelate is presented. PARACEST agents are ideally suited for molecular imaging applications because one can switch the contrast on and off at will simply by adjusting the pulse sequence parameters. This obviates the need for pre‐ and postinjection images to define contrast agent binding. Spectroscopy (4.7T) of PARACEST nanoparticles revealed a bound water peak at 52 ppm, in agreement with results from the water‐soluble chelate. Imaging of control nanoparticles showed no appreciable contrast, while PARACEST nanoparticles produced >10% signal enhancement. PARACEST nanoparticles were targeted to clots via antifibrin antibodies and produced a contrast‐to‐noise ratio (CNR) of 10 at the clot surface. Magn Reson Med, 2006.Keywords
This publication has 21 references indexed in Scilit:
- Applications of Nanotechnology to Atherosclerosis, Thrombosis, and Vascular BiologyArteriosclerosis, Thrombosis, and Vascular Biology, 2006
- Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): Ph calibration for poly‐L‐lysine and a starburst dendrimerMagnetic Resonance in Medicine, 2006
- Heart Disease and Stroke Statistics—2006 UpdateCirculation, 2006
- Intracoronary Thermography: Does It Help Us in Clinical Decision Making?Journal of Interventional Cardiology, 2005
- Highly Sensitive MRI Chemical Exchange Saturation Transfer Agents Using LiposomesAngewandte Chemie-International Edition, 2005
- Imaging of Atherosclerosis — Can We Predict Plaque Rupture?Trends in Cardiovascular Medicine, 2005
- Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experimentsMagnetic Resonance in Medicine, 2004
- Supramolecular Adducts between Poly‐L‐arginine and [TmIIIdotp]: A Route to Sensitivity‐Enhanced Magnetic Resonance Imaging–Chemical Exchange Saturation Transfer AgentsAngewandte Chemie-International Edition, 2003
- Improved molecular imaging contrast agent for detection of human thrombusMagnetic Resonance in Medicine, 2003
- Generation and partial characterization of five monoclonal antibodies with high affinities for fibrinBlood Coagulation & Fibrinolysis, 1993