Factors influencing peritoneal transport parameters during the first year on peritoneal dialysis: peritonitis is the main factor

Abstract

Background. Studies on the evolution of peritoneal transport during the first year of peritoneal dialysis (PD) are scarce and their results are contradictory. The aim of the present study was to analyse the evolution of peritoneal transport and residual renal function during the first year on PD, and to determine the factors that may influence them. Methods. We studied 249 patients on continuous ambulatory PD with glucose exchange solutions (117 men, 132 women, mean age 51.9±16 years) 59 of whom had diabetes (25 type I). At baseline and after 1 year, we determined the mass transfer coefficients of urea (U-MTAC) and creatinine (Cr-MTAC), net ultrafiltration and residual renal function. Results. Residual renal function decreased significantly during the first year (from 3.9±2.8 to 2.4±2.2 ml/min, PPPn = 88) showed a first year increase in Cr-MTAC, which was significantly higher than in patients without peritonitis (11.1±5 vs 9.5±4.2, PConclusions. The peritoneal transport parameters tended toward normalization during the first year on PD, mainly with a decrease of small solute transport and an increase of ultrafiltration capacity. This evolution is independent of age, gender, diabetes and higher exposure to glucose in PD solutions. Peritonitis was the only independent factor that affected peritoneal function during the first year on peritoneal dialysis.