Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand
Open Access
- 9 June 2014
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 5 (1), 1-13
- https://doi.org/10.1038/ncomms5092
Abstract
Dendritic cells (DCs) play a critical role in immune homeostasis by regulating the functions of various immune cells, including T and B cells. Notably, DCs also undergo education on reciprocal signalling by these immune cells and environmental factors. Various reports demonstrated that B cells have profound regulatory functions, although only few reports have explored the regulation of human DCs by B cells. Here we demonstrate that activated but not resting B cells induce maturation of DCs with distinct features to polarize Th2 cells that secrete interleukin (IL)-5, IL-4 and IL-13. B-cell-induced maturation of DCs is contact dependent and implicates signalling of B-cell activation molecules CD69, B-cell-activating factor receptor, and transmembrane activator and calcium-modulating cyclophilin ligand interactor. Mechanistically, differentiation of Th2 cells by B-cell-matured DCs is dependent on OX-40 ligand. Collectively, our results suggest that B cells have the ability to control their own effector functions by enhancing the ability of human DCs to mediate Th2 differentiation.This publication has 71 references indexed in Scilit:
- Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cellsNature Immunology, 2012
- B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cellsThe Journal of Experimental Medicine, 2012
- Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological toleranceProceedings of the National Academy of Sciences of the United States of America, 2012
- T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elementsNature Communications, 2012
- Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammationThe Journal of Experimental Medicine, 2011
- B-cell delivered gene therapy for tolerance induction: Role of autoantigen-specific B cellsJournal of Autoimmunity, 2010
- Effector and regulatory B cells: modulators of CD4+ T cell immunityNature Reviews Immunology, 2010
- The significance of OX40 and OX40L to T‐cell biology and immune diseaseImmunological Reviews, 2009
- Orchestrating the orchestrators: chemokines in control of T cell trafficNature Immunology, 2008
- Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthmaNature Medicine, 2008