Transcriptional and post-translational regulation of adiponectin
- 14 December 2009
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 425 (1), 41-52
- https://doi.org/10.1042/bj20091045
Abstract
Adiponectin is an adipose-tissue-derived hormone with anti-diabetic, anti-atherogenic and anti-inflammatory functions. Adiponectin circulates in the bloodstream in trimeric, hexameric and high-molecular-mass species, and different forms of adiponectin have been found to play distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with obesity and insulin resistance, yet the underlying mechanisms remain elusive. In the present review, we summarize recent progress made on the mechanisms regulating adiponectin gene transcription, multimerization and secretion. We also discuss the potential relevance of these studies to the development of new clinical therapy for insulin resistance, Type 2 diabetes and other obesity-related metabolic disorders.Keywords
This publication has 168 references indexed in Scilit:
- IGFBP-3, hypoxia and TNF-α inhibit adiponectin transcriptionBiochemical and Biophysical Research Communications, 2009
- Adipocyte CREB Promotes Insulin Resistance in ObesityCell Metabolism, 2009
- Emerging role of adipose tissue hypoxia in obesity and insulin resistanceInternational Journal of Obesity, 2008
- DsbA-L is a versatile player in adiponectin secretionProceedings of the National Academy of Sciences of the United States of America, 2008
- A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerizationProceedings of the National Academy of Sciences of the United States of America, 2008
- SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in MiceCell Metabolism, 2008
- Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2Nature, 2007
- Inflammation and metabolic disordersNature, 2006
- Decreased Expression of Adipogenic Genes in Obese Subjects with Type 2 DiabetesObesity, 2006
- Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γNature, 2004