How colonization by microbiota in early life shapes the immune system
Top Cited Papers
- 29 April 2016
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 352 (6285), 539-544
- https://doi.org/10.1126/science.aad9378
Abstract
Microbial colonization of mucosal tissues during infancy plays an instrumental role in the development and education of the host mammalian immune system. These early-life events can have long-standing consequences: facilitating tolerance to environmental exposures or contributing to the development of disease in later life, including inflammatory bowel disease, allergy, and asthma. Recent studies have begun to define a critical period during early development in which disruption of optimal host-commensal interactions can lead to persistent and in some cases irreversible defects in the development and training of specific immune subsets. Here, we discuss the role of early-life education of the immune system during this “window of opportunity,” when microbial colonization has a potentially critical impact on human health and disease.Funding Information
- Harvard Digestive Diseases Center (DK0034854)
- NIH (DK44319, R21 AI090102)
- U.S. Department of Defense (W81XWH-15-1-0368)
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