General Catalytic Methylation of Amines with Formic Acid under Mild Reaction Conditions
- 28 May 2014
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 20 (26), 7878-7883
- https://doi.org/10.1002/chem.201402124
Abstract
A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including [N‐13C]‐labelled drugs in good to excellent yields under mild conditions.This publication has 71 references indexed in Scilit:
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