Tolerance and Chimerism after Renal and Hematopoietic-Cell Transplantation
Top Cited Papers
- 24 January 2008
- journal article
- case report
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 358 (4), 362-368
- https://doi.org/10.1056/nejmoa074191
Abstract
We describe a recipient of combined kidney and hematopoietic-cell transplants from an HLA-matched donor. A post-transplantation conditioning regimen of total lymphoid irradiation and antithymocyte globulin allowed engraftment of the donor's hematopoietic cells. The patient had persistent mixed chimerism, and the function of the kidney allograft has been normal for more than 28 months since discontinuation of all immunosuppressive drugs. Adverse events requiring hospitalization were limited to a 2-day episode of fever with neutropenia. The patient has had neither rejection episodes nor clinical manifestations of graft-versus-host disease.Keywords
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