A Two-Stage Exon Recognition Model Based on Synergetic Neural Network
Open Access
- 1 January 2014
- journal article
- research article
- Published by Hindawi Limited in Computational and Mathematical Methods in Medicine
- Vol. 2014, 1-7
- https://doi.org/10.1155/2014/503132
Abstract
Exon recognition is a fundamental task in bioinformatics to identify the exons of DNA sequence. Currently, exon recognition algorithms based on digital signal processing techniques have been widely used. Unfortunately, these methods require many calculations, resulting in low recognition efficiency. In order to overcome this limitation, a two-stage exon recognition model is proposed and implemented in this paper. There are three main works. Firstly, we use synergetic neural network to rapidly determine initial exon intervals. Secondly, adaptive sliding window is used to accurately discriminate the final exon intervals. Finally, parameter optimization based on artificial fish swarm algorithm is used to determine different species thresholds and corresponding adjustment parameters of adaptive windows. Experimental results show that the proposed model has better performance for exon recognition and provides a practical solution and a promising future for other recognition tasks.Keywords
Funding Information
- National Natural Science Foundation of China (61005052, 2010121068, 2011J01369, 2012Z91)
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