Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
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Open Access
- 30 September 2016
- journal article
- review article
- Published by American Chemical Society (ACS) in Chemical Reviews
- Vol. 116 (19), 12564-12649
- https://doi.org/10.1021/acs.chemrev.6b00512
Abstract
Pd-catalyzed cross-coupling reactions that form C-N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C-N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.Keywords
Funding Information
- National Institutes of Health (GM58160)
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