Urotensin II evokes potent vasoconstriction in humans in vivo
- 29 January 2002
- journal article
- clinical trial
- Published by Wiley in British Journal of Pharmacology
- Vol. 135 (1), 25-27
- https://doi.org/10.1038/sj.bjp.0704448
Abstract
The peptide urotensin II (U II) evokes potent vasoconstriction in non-human primates. In human blood vessels studied in vitro variable effects of U II are reported; vasoconstriction, vasodilatation or no response. It is therefore of importance to determine the vascular effect of U II in humans in vivo. U II (0.1 - 300 pmol min(-1)) was infused into the brachial artery of nine healthy volunteers. Changes in forearm blood flow (FBF) were determined by venous occlusion plethysmography. U II induced dose-dependent reduction in FBF. A threshold response was obtained by 1 pmol min(-1), and the highest dose of U II (300 pmol min(-1)) reduced FBF by 31+/-4% (P<0.01). FBF returned to baseline values within 30 min. This study demonstrates that U II produces potent vasoconstriction in humans in vivo.This publication has 9 references indexed in Scilit:
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