Attenuated hepatosplanchnic uptake of lactate during intense exercise in humans
- 1 April 2002
- journal article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 92 (4), 1677-1683
- https://doi.org/10.1152/japplphysiol.00028.2001
Abstract
We evaluated whether the increase in blood lactate with intense exercise is influenced by a low hepatosplanchnic blood flow as assessed by indocyanine green dye elimination and blood sampling from an artery and the hepatic vein in eight men. The hepatosplanchnic blood flow decreased from a resting value of 1.6 ± 0.1 to 0.7 ± 0.1 (SE) l/min during exercise. Yet the hepatosplanchnic O2uptake increased from 67 ± 3 to 93 ± 13 ml/min, and the output of glucose increased from 1.1 ± 0.1 to 2.1 ± 0.3 mmol/min ( P < 0.05). Even at the lowest hepatosplanchnic venous hemoglobin O2 saturation during exercise of 6%, the average concentration of glucose in arterial blood was maintained close to the resting level (5.2 ± 0.2 vs. 5.5 ± 0.2 mmol/l), whereas the difference between arterial and hepatic venous blood glucose increased to a maximum of 22 mmol/l. In arterial blood, the concentration of lactate increased from 1.1 ± 0.2 to 6.0 ± 1.0 mmol/l, and the hepatosplanchnic uptake of lactate was elevated from 0.4 ± 0.06 to 1.0 ± 0.05 mmol/min during exercise ( P < 0.05). However, when the hepatosplanchnic venous hemoglobin O2 saturation became low, the arterial and hepatosplanchnic venous blood lactate difference approached zero. Even with a marked reduction in its blood flow, exercise did not challenge the ability of the liver to maintain blood glucose homeostasis. However, it appeared that the contribution of the Cori cycle decreased, and the accumulation of lactate in blood became influenced by the reduced hepatosplanchnic blood flow.Keywords
This publication has 37 references indexed in Scilit:
- Effect of hyperoxia on aerobic and anaerobic performances and muscle metabolism during maximal cycling exerciseActa Physiologica Scandinavica, 2000
- Lactate, glucose and O2 uptake in human brain during recovery from maximal exerciseThe Journal of Physiology, 2000
- Preserved arterial flow secures hepatic oxygenation during haemorrhage in the pigThe Journal of Physiology, 1999
- Noninvasive Cardiac Output: Simultaneous Comparison of Two Different Methods with ThermodilutionAnesthesiology, 1990
- Derecruitment in cat liver: extension of undistributed parallel tube model to effects of low hepatic blood flow on ethanol uptakeCanadian Journal of Physiology and Pharmacology, 1989
- Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in manLiver International, 1987
- POLICY STATEMENT REGARDING THE USE OF HUMAN SUBJECTS AND INFORMED CONSENTMedicine & Science in Sports & Exercise, 1982
- Central and Regional Circulatory Effects of Adding Arm Exercise to Leg ExerciseActa Physiologica Scandinavica, 1977
- Indocyanine Green Clearance and Estimated Hepatic Blood Flow during Mild to Maximal Exercise in Upright Man *JCI Insight, 1964
- Myorcardial Metabolism of Glucose, Lactic Acid, Amino Acids and Fatty Acids in Healthy Human Individuals at Rest and at Different Work LoadsScandinavian Journal of Clinical and Laboratory Investigation, 1961