Solvent-Free Synthesis of Functionalized Flavones under Microwave Irradiation
- 4 March 2005
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 70 (7), 2855-2858
- https://doi.org/10.1021/jo048685z
Abstract
Eco-friendly direct solvent-free synthesis of flavones is achieved by microwave irradiation of phloroglucinol and β-ketoesters. Heating with microwaves versus under classical conditions was shown to be higher yielding, cleaner, and faster. The reaction goes through a cycloaddition of an α-oxo ketene intermediate followed by an uncatalyzed thermal Fries rearrangement.Keywords
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