Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease
- 15 December 2018
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 145 (24), dev171983
- https://doi.org/10.1242/dev.171983
Abstract
Embryonic and postnatal life depend on the uninterrupted function of cardiac muscle cells. These cells, termed cardiomyocytes, display many fascinating behaviors, including complex morphogenic movements, interactions with other cell types of the heart, persistent contractility and quiescence after birth. Each of these behaviors depends on complex interactions between both cardiac-restricted and widely expressed transcription factors, as well as on epigenetic modifications. Here, we review recent advances in our understanding of the genetic and epigenetic control of cardiomyocyte differentiation and proliferation during heart development, regeneration and disease. We focus on those regulators that are required for both heart development and disease, and highlight the regenerative principles that might be manipulated to restore function to the injured adult heart.Keywords
Funding Information
- National Institutes of Health (AR-067294)
- Fondation Leducq
- Welch Foundation (1-0025)
This publication has 155 references indexed in Scilit:
- Heart repair by reprogramming non-myocytes with cardiac transcription factorsNature, 2012
- Transcription Factor Pathways and Congenital Heart DiseasePublished by Elsevier BV ,2012
- Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasisNature Genetics, 2012
- Large-scale discovery of enhancers from human heart tissueNature Genetics, 2011
- Chromatin remodelling complex dosage modulates transcription factor function in heart developmentNature Communications, 2011
- Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined FactorsCell, 2010
- Chromatin regulation by Brg1 underlies heart muscle development and diseaseNature, 2010
- Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferationNature, 2010
- Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in miceDevelopmental Biology, 2008
- GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5Nature, 2003